BK-1361 ( BK 1361;BK1361;cyclo-RLsKDK )

产品货号. M21713 CAS No. 1975145-82-4

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

BK-1361
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM.
产品描述

BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM; inhibit shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology; decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC.
同义词

BK 1361;BK1361;cyclo-RLsKDK
通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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1. Yim V, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4032-4037.

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