BI-2536
CAS No. 755038-02-9
BI-2536 ( BI 2536;BI2536 )
产品货号. M15870 CAS No. 755038-02-9
A potent and selective inhibitor of PLK1 with IC50 of 0.83 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥437 | 有现货 |
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5MG | ¥721 | 有现货 |
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25MG | ¥1021 | 有现货 |
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50MG | ¥1677 | 有现货 |
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100MG | ¥2989 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BI-2536
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A potent and selective inhibitor of PLK1 with IC50 of 0.83 nM.
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产品描述A potent and selective inhibitor of PLK1 with IC50 of 0.83 nM; also weakly inhibits the activities of PLK2 and PLK3 (IC50=3.5 nM and 9.0 nM, respectively), displays >1,000-fold selectivity to a panel of 63 other protein kinases; causes a mitotic arrest and induces apoptosis in human cancer cell lines, inhibits growth of human tumor xenografts in nude mice and induces regression of large tumors with well-tolerated intravenous dose regimens; also inhibits BRD4 with IC50 of 25 nM.Blood Cancer Phase 2 Clinical
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同义词BI 2536;BI2536
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通路Cell Cycle/DNA Damage
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靶点PLK
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受体Met;PI3Kα;PLK1;PLK2;PLK3
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number755038-02-9
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分子量521.65
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分子式C28H39N7O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(NC1CCN(C)CC1)C2=CC=C(NC(N=C3N(C4CCCC4)[C@@H]5CC)=NC=C3N(C)C5=O)C(OC)=C2
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化学全称Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
2. Chen L, et al. ACS Med Chem Lett. 2015 May 18;6(7):764-9.
3. Nappi TC, et al. Cancer Res. 2009 Mar 1;69(5):1916-23.
产品手册
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