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BC-1471
CAS No. 896683-78-6
BC-1471 ( —— )
产品货号. M22992 CAS No. 896683-78-6
BC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1320 | 有现货 |
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| 10MG | ￥2130 | 有现货 |
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| 25MG | ￥4560 | 有现货 |
|
| 50MG | ￥6577 | 有现货 |
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| 100MG | ￥9153 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BC-1471
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?
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产品描述BC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?These findings describe a unique pathway of inflammasome regulation with the identification of STAMBP as a potential therapeutic target to reduce pro-inflammatory stress.
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同义词——
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通路Others
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靶点Other Targets
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受体deubiquitinase STAM-binding protein (STAMBP)
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研究领域——
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适应症——
化学信息
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CAS Number896683-78-6
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分子量504.6
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分子式C27H28N4O4S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NCC1=CC=CO1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Joseph S Bednash, Nathaniel Weathington, James Londino.Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity.Nat Commun. 2017 May 11;8:15203.
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