BAZ1A-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BAZ1A-IN-1 是一种有效的 BAZ1A 抑制剂，对于 BAZ1A bromodomain 的 KD 值为 0.52 μM。 BAZ1A-IN-1对BAZ1A高表达的癌细胞系表现出良好的抗生存活性，但对BAZ1A低表达的癌细胞表现出弱或无活性。

BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell lines with high BAZ1A expression, but weak or no activity against cancer cells with low BAZ1A expression.(In Vitro):Administration of BAZ1A-IN-1 (0.015-100?μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively.

Cell Viability Assay Cell Line:THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells Concentration:0.015-100 ?μM Incubation Time:96 hours Result:Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A.

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Chromatin/Epigenetic

Epigenetic Reader Domain

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941521-45-5

680.71

C32H24N8O6S2

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (73.45 mM)

[O-][N+](c1cccc(NC(Nc2nc(-c3ccccc3)cs2)=O)c1)=O[O-][N+](c1cccc(NC(Nc2nc(-c3ccccc3)cs2)=O)c1)=O

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(-20℃)

With Ice Pack

≥ 2 years