BAY1217389 ( BAY1217389; BAY-1217389; BAY 1217389 )

产品货号. M18080 CAS No. 1554458-53-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

BAY1217389
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
产品描述

BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells.
同义词

BAY1217389; BAY-1217389; BAY 1217389
通路

Others
靶点

Other Targets
受体

Mps1
研究领域

Cancer
适应症

——

CAS Number

1554458-53-5
分子量

561.5
分子式

C27H24F5N5O3
纯度

98%
溶解度

DMSO : ≥ 28 mg/mL; 49.87 mM
SMILES

Cc1c(ccc(c1)c1cnc2n1nc(cc2NCCC(F)(F)F)Oc1c(c(c(cc1)OC)F)F)C(=O)NC1CC1
化学全称

N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide

1.Wengner AM, et al. Mol Cancer Ther. 2016 Apr;15(4):583-92.

计算器

产品手册

关联产品

2-chloro-5-(16,18-di...

2-chloro-5-(16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid is a chemical compound
4-Methoxycoumarine

4-Methoxycoumarine has antitumour effects.Coumarin has antitumour effects in vivo and cytostatic effects in vitro. Its half-life in humans is short (1-1.5 h) and the monohydroxylated biotransformation products have significantly longer half-lives.
Carbetocin acetate(3...

Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.