BAY-678

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BAY-678 是具有口服生物活性的、高效的、选择性的、人中性粒细胞弹性蛋白酶 (HNE) 的细胞渗透性抑制剂，其 IC50 值为 20 nM。BAY-678 也是被基因结构组学联盟 (SGC) 推荐的化学探针。

BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. The Ki value of BAY-678 for MNE is 700 nM. BAY-678 is the 4th generation inhibitor of HNE. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). BAY-678 has more than 2,000-fold selectivity in a panel of 21 serine proteases.

BAY-678 (17) reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating their anti-inflammatory and anti-remodeling mode of action. Additionally, BAY-678 (17) has shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.

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Others

Other Targets

Others

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675103-36-3

400.35

C20H15F3N4O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (249.78 mM ) Ethanol 中的溶解度 : ≥ 4.76 mg/mL (11.89 mM)

CC(=O)C1=C(C)N(C(=O)N[C@@H]1c1ccc(nc1)C#N)c1cccc(c1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years