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BAW2881

CAS No. 861875-60-7

BAW2881 ( BAW2881 | BAW-2881 | BAW 2881 )

产品货号. M17624 CAS No. 861875-60-7

BAW2881 是一种有效的选择性 VEGFR 抑制剂(血管内皮生长因子受体酪氨酸激酶抑制剂),具有抑制慢性和急性皮肤炎症的活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥348 有现货
5MG ¥551 有现货
10MG ¥948 有现货
25MG ¥1806 有现货
50MG ¥2916 有现货
100MG ¥4228 有现货
500MG ¥9477 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    BAW2881
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    BAW2881 是一种有效的选择性 VEGFR 抑制剂(血管内皮生长因子受体酪氨酸激酶抑制剂),具有抑制慢性和急性皮肤炎症的活性。
  • 产品描述
    BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation. NVP-BAW2881 inhibited proliferation, migration, and tube formation by human umbilical vein endothelial cells and lymphatic endothelial cells in vitro. NVP-BAW2881 reduced the number of blood and lymphatic vessels and infiltrating leukocytes in the skin, and normalized the epidermal architecture. NVP-BAW2881 also displayed strong anti-inflammatory effects in models of acute inflammation; pretreatment with topical NVP-BAW2881 significantly inhibited VEGF-A-induced vascular permeability in the skin of pigs and mice.
  • 体外实验
    The VEGF-driven cellular receptor autophosphorylation in CHO cells of BAW2881 is inhibited with an IC50 of 4 nM. BAW2881 inhibits a limited number of kinases including c-RAF, B-RAF, RET, ABL, and TIE-2 at sub-μM IC50s. NVP-BAW2881 is highly selective for VEGFR, although it also demonstrates activity against Tie2 (IC50=650 nM) and RET (IC50=410 nM). The IC50 values of NVP-BAW2881 toward a wide panel of other kinases are >10 μM. NVP-BAW2881 inhibits VEGF-A-induced phosphorylation of VEGFR-2 in HUVECs and in VEGFR-2-transfected Chinese hamster ovary cells, with IC50 values of 2.9 and 4.2 nM, respectively.
  • 体内实验
    In a transgenic mouse model of psoriasis, NVP-BAW2881 reduces the number of blood and lymphatic vessels and infiltrating leukocytes in the skin, and normalized the epidermal architecture. NVP-BAW2881 also displays strong anti-inflammatory effects in models of acute inflammation; pretreatment with topical NVP-BAW2881 significantly inhibits VEGF-A-induced vascular permeability in the skin of pigs and mice.
  • 同义词
    BAW2881 | BAW-2881 | BAW 2881
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    c-Abl| B-Raf (V599E)| C-Raf-1| hVEGFR2
  • 研究领域
    Endocrinology
  • 适应症
    ——

化学信息

  • CAS Number
    861875-60-7
  • 分子量
    424.38
  • 分子式
    C22H15F3N4O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 33 mg/mL; 77.76 mM
  • SMILES
    O=C(c1c2ccc(Oc3nc(N)ncc3)cc2ccc1)Nc1cccc(C(F)(F)F)c1
  • 化学全称
    6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Halin C, et al. Am J Pathol. 2008 Jul;173(1):265-77.
产品手册
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