Azithromycin ( CP 62993 )

产品货号. M16114 CAS No. 83905-01-5

一种大环内酯类抗生素，用于治疗多种细菌感染。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
50MG	￥454	有现货
100MG	￥680	有现货
500MG	￥1774	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Azithromycin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种大环内酯类抗生素，用于治疗多种细菌感染。
产品描述

A macrolide antibiotic used for the treatment of a number of bacterial infections; also attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4; also blocks autophagy by preventing lysosomal acidification.Bacterial Infection Approved(In Vitro):Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells.(In Vivo):Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice.
体外实验

Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells.
体内实验

Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice.
同义词

CP 62993
通路

GPCR/G Protein
靶点

Antibacterial
受体

proteinsynthesis
研究领域

Infection
适应症

Bacterial Infection

化学信息

CAS Number

83905-01-5
分子量

748.9845
分子式

C38H72N2O12
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
化学全称

1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Tsubouchi K, et al. Autophagy. 2017 Jun 14:1-15. 2. Moriya S, et al. Int J Oncol. 2013 May;42(5):1541-50. 3. Renna M, et al. J Clin Invest. 2011 Sep;121(9):3554-63.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册