Azido-PEG2-C6-Cl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Azido-PEG2-C6-Cl 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。Azido-PEG2-C6-Cl 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。

Azido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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PROTACs

PROTAC

PROTAC Linker

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2568146-55-2

249.74

C10H20ClN3O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (1001.04 mM; 超声助溶 )

[N-]=[N+]=NCCOCCOCCCCCCCl

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(-20℃)

With Ice Pack

≥ 2 years