Axitinib-13C-d3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Axitinib-13C,d3 是一种 13C 标记和氘代标记 Axitinib。Axitinib是多靶点的酪氨酸激酶抑制剂，抑制 VEGFR1，VEGFR2，VEGFR3， PDGFRβ 的 IC50 值分别为4，20，4，2 nM。

Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 andPDGFRβ, respectively.

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Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

阿昔替尼杂质

Others

Other Targets

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1261432-00-1

390.48

C2113CH15D3N4OS

>98% (HPLC)

DMSO : ≥ 2.5 mg/mL (6.40 mM ) DMF : ≥ 0.25 mg/mL (0.64 mM)

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(-20℃)

With Ice Pack

≥ 2 years