Avoralstat ( BCX4161 )

产品货号. M24967 CAS No. 918407-35-9

Avoralstat 是一种口服血浆激肽释放酶 (PKK) 抑制剂。用于治疗遗传性血管性水肿。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥551	有现货
5MG	￥915	有现货
10MG	￥1393	有现货
25MG	￥2811	有现货
50MG	￥4277	有现货
100MG	￥6229	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Avoralstat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Avoralstat 是一种口服血浆激肽释放酶 (PKK) 抑制剂。用于治疗遗传性血管性水肿。
产品描述

Avoralstat is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema. (In Vitro):C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).
体外实验

C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).
体内实验

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同义词

BCX4161
通路

Others
靶点

Other Targets
受体

plasma kallikrein (PKK)
研究领域

——
适应症

——

化学信息

CAS Number

918407-35-9
分子量

513.54
分子式

C28H27N5O5
纯度

>98% (HPLC)
溶解度

DMSO:50 mg/mL (97.36 mM; Need ultrasonic)
SMILES

COc(c(C=C)c1)cc(-c2ccc(C(NCC3CC3)=O)nc2C(O)=O)c1C(Nc(cc1)ccc1C(N)=N)=O
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5.

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分子量计算器

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