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Avoralstat

CAS No. 918407-35-9

Avoralstat ( BCX4161 )

产品货号. M24967 CAS No. 918407-35-9

Avoralstat 是一种口服血浆激肽释放酶 (PKK) 抑制剂。用于治疗遗传性血管性水肿。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥551 有现货
5MG ¥915 有现货
10MG ¥1393 有现货
25MG ¥2811 有现货
50MG ¥4277 有现货
100MG ¥6229 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Avoralstat
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Avoralstat 是一种口服血浆激肽释放酶 (PKK) 抑制剂。用于治疗遗传性血管性水肿。
  • 产品描述
    Avoralstat is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema. (In Vitro):C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).
  • 体外实验
    C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).
  • 体内实验
    ——
  • 同义词
    BCX4161
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    plasma kallikrein (PKK)
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    918407-35-9
  • 分子量
    513.54
  • 分子式
    C28H27N5O5
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:50 mg/mL (97.36 mM; Need ultrasonic)
  • SMILES
    COc(c(C=C)c1)cc(-c2ccc(C(NCC3CC3)=O)nc2C(O)=O)c1C(Nc(cc1)ccc1C(N)=N)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5.
产品手册
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