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Auranofin

CAS No. 34031-32-8

Auranofin ( NSC 321521 | Ridauragold thiol | SKF 39162 )

产品货号. M14154 CAS No. 34031-32-8

金诺芬是一种抗风湿药,用于治疗类风湿性关节炎。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥316 有现货
10MG ¥494 有现货
25MG ¥1021 有现货
50MG ¥1871 有现货
100MG ¥2624 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Auranofin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    金诺芬是一种抗风湿药,用于治疗类风湿性关节炎。
  • 产品描述
    Auranofin is an antirheumatic agent, is used to treat rheumatoid arthritis, improves arthritis symptoms including painful or tender and swollen joints and morning stiffness.(In Vitro):Auranofin is a drug that is approved for the treatment of rheumatoid arthritis but is being investigated for potential therapeutic application in a number of other diseases including cancer, neurodegenerative disorders. Auranofin induces apoptosis in cells through a Bax/Bak-dependent mechanism associated with selective disruption of mitochondrial redox homeostasis in conjunction with oxidation of Prx3. Auranofin inhibits proliferation and survival of SKOV3 cells in a dose- and time-dependent manner. Auranofin treatment activates the pro-apoptotic caspase-3, increases protein levels of apoptosis-inducing proteins Bax and Bim and reduces the expression of the anti-apoptotic mediator Bcl-2 in SKOV3 cells. Auranofin is a lipophilic gold compound with anti-inflammatory and immunosuppressive properties. Auranofin inhibits the cell growth and induction of mitochondrial apoptosis in PC3 human prostate cancer cells. Treatment with auranofin significantly inhibits cell viability with an IC50 value of 2.5 μM after 24 h.(In Vivo):Prophylactic treatment of adjuvant-induced arthritis rats with auranofin results in a slight reduction in paw edema, a complete normalization of the depressed IL-2 production, and a reduction of the elevated IL-1 production, but has no effect on the depressed IL-3 production.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    NSC 321521 | Ridauragold thiol | SKF 39162
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    TrxR
  • 研究领域
    Inflammation/Immunology
  • 适应症
    ——

化学信息

  • CAS Number
    34031-32-8
  • 分子量
    678.48
  • 分子式
    C20H34AuO9PS
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 10 mM
  • SMILES
    CC(OC[C@H]1O[C@@H](S[Au]=P(CC)(CC)CC)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)=O
  • 化学全称
    (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Rigobello MP, et al. Free Radic Res. 2005 Jul; 39(7):687-95.
产品手册
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