Aromadendrin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

香薰素是一种天然产品。它诱导细胞凋亡并抑制 Bcl-2 和 Bcl-xL 表达，具有抗炎、抗氧化和抗糖尿病特性，具有抗炎活性。Aromadendrin 是一种黄酮醇，据报道具有多种药理活性，例如- 抗炎、抗氧化和抗糖尿病特性。

Aromadendrin is a natural product.?It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression,?possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activityAromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties.?Aromadendrin significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2.?In accordance, aromadendrin attenuated LPSinduced overexpression iNOS and COX-2.?In addition, aromadendrin significantly suppressed LPS-induced degradation of IκB, which sequesters NF-κB in cytoplasm, consequently inhibiting the nuclear translocation of pro-inflammatory transcription factor NF- κB.?Aromadendrin significantly attenuated LPS-induced activation of JNK, but not ERK and p38, in a concentration-dependent manner.?Aromadendrin exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells.

Cell Proliferation Assay Cell Line:Normal synoviocyte cells; RA-FLS cells Concentration:0.3 μM, 3 μM, 30 μM, 300 μM Incubation Time:48 hours Result:Decreased the proliferation of RA-FLSs.Apoptosis Analysis Cell Line:RA-FLS cells Concentration:3 μM, 30 μM Incubation Time:48 hours Result:Induced apoptosis in RA-FLSs.Western Blot Analysis Cell Line:RA-FLS cells Concentration:3 μM, 30 μM Incubation Time:48 hours Result:Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression.

——

——

Angiogenesis

Bcl-2

Bcl-2|Bcl-xL

——

——

480-20-6

288.3

C15H12O6

>98% (HPLC)

DMSO:120 mg/mL (416.31 mM; Need ultrasonic); H2O:< 0.1 mg/mL (insoluble)

O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC=C(O)C=C3)[C@H]1O

——

(-20℃)

With Ice Pack

≥ 2 years