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Arazine

CAS No. 135304-07-3

Arazine ( N-Acetyl-S-farnesyl-L-cysteine )

产品货号. M26060 CAS No. 135304-07-3

Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2082 有现货
10MG ¥3070 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Arazine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.
  • 产品描述
    Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.(In Vitro):Arazine (10–100 μM; 8h) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell. Arazine (2h) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell.(In Vivo):Arazine (2,000 μg/20 μl) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with an ED50 of 55 μg/20 μl.
  • 同义词
    N-Acetyl-S-farnesyl-L-cysteine
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    S1PR4
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    135304-07-3
  • 分子量
    367.6
  • 分子式
    C20H33NO3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    O=C(O)[C@H](CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)NC(C)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Guerrero M,et,al.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6.
产品手册
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