Arazine
CAS No. 135304-07-3
Arazine ( N-Acetyl-S-farnesyl-L-cysteine )
产品货号. M26060 CAS No. 135304-07-3
Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2082 | 有现货 |
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10MG | ¥3070 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Arazine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.
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产品描述Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.(In Vitro):Arazine (10–100 μM; 8h) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell. Arazine (2h) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell.(In Vivo):Arazine (2,000 μg/20 μl) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with an ED50 of 55 μg/20 μl.
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同义词N-Acetyl-S-farnesyl-L-cysteine
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通路Others
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靶点Other Targets
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受体S1PR4
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研究领域——
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适应症——
化学信息
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CAS Number135304-07-3
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分子量367.6
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分子式C20H33NO3S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(O)[C@H](CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)NC(C)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Guerrero M,et,al.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6.
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