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Aprepitant
CAS No. 170729-80-3
Aprepitant ( MK-0869;MK-869;L-754030 )
产品货号. M12607 CAS No. 170729-80-3
A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥389 | 有现货 |
|
| 10MG | ￥470 | 有现货 |
|
| 50MG | ￥656 | 有现货 |
|
| 100MG | ￥794 | 有现货 |
|
| 200MG | ￥948 | 有现货 |
|
| 500MG | ￥1199 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Aprepitant
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
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产品描述A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM; blocks NK-1 agonist-induced foot tapping response in gerbils and shows antiemetic actions in the ferret against cisplatin challenge; has the potentiation for the treatment of peripheral pain, migraine, chemotherapy-induced emesis, and various psychiatric disorders.Chemotherapeutic Agents Approved
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同义词MK-0869;MK-869;L-754030
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通路GPCR/G Protein
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靶点Neurokinin Receptor
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受体NK1
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研究领域Cancer
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适应症Chemotherapeutic
化学信息
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CAS Number170729-80-3
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分子量534.43
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分子式C23H21F7N4O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C1NNC(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)OCC2)=N1
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化学全称3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kramer MS, et al. Science. 1998 Sep 11;281(5383):1640-5.
2. Hale JJ, et al. J Med Chem. 1998 Nov 5;41(23):4607-14.
3. Tattersall FD, et al. Neuropharmacology. 2000 Feb 14;39(4):652-63.
2. Hale JJ, et al. J Med Chem. 1998 Nov 5;41(23):4607-14.
3. Tattersall FD, et al. Neuropharmacology. 2000 Feb 14;39(4):652-63.
产品手册
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