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Apoptozole

CAS No. 1054543-47-3

Apoptozole ( Apoptozole | Apoptosis Activator VII )

产品货号. M17785 CAS No. 1054543-47-3

Apoptozole 是 Hsc70 和 Hsp70 ATPase 结构域的抑制剂,可诱导细胞凋亡。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥348 有现货
10MG ¥616 有现货
25MG ¥1126 有现货
50MG ¥2001 有现货
100MG ¥2981 有现货
200MG ¥4398 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Apoptozole
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Apoptozole 是 Hsc70 和 Hsp70 ATPase 结构域的抑制剂,可诱导细胞凋亡。
  • 产品描述
    Apoptozole, also known as Apoptosis Activator VII, is a selective inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. Apoptozole enhances immune responses to administered antigens. Treatment of mice with Apoptozole elicits production of antibodies with a high IgG2c/IgG1 ratio and stimulates the release of Th1 and Th2-type cytokines, suggesting that Apoptozole activates the Th1 and Th2 immune responses. The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes.
  • 体外实验
    Apoptozole is an inhibitor of Hsc70 and Hsp70, which binds to Hsc70 and Hsp70, with Kds of 0.21 and 0.14?μM, respectively. Apoptozole (Apoptosis Activator VII; 1?μM) induces apoptosis in P19 cells. Apoptozole shows inhibitory activities against several cancer cell lines, such as SK-OV-3 (ovarian cancer cells), HCT-15 (colon cancer cells), and A549 (lung cancer cells), with IC50s of 0.22, 0.25, and 0.13?μM, respectively. Apoptozole binds to the ATPase domain of Hsc70 and Hsp70, but does not binds to other types of heat shock proteins such as Hsp60, Hsp90 or Hsp40. Apoptozole (0-15 μM) suppresses the growth of A549 cells, HeLa cells, and MDA-MB-231 cells, with IC50s ranging from 5 to 7 μM. Apoptozole (5 or 10 μM) shows no effect on associations of HSP70 with ASK1, JNK, or BAX, and does not induce AIF-mediated caspase-independent apoptosis in HeLa cells.
  • 体内实验
    Apoptozole (Apoptosis Activator VII; 4 mg/kg, i.p.) exhibits antitumor activities in nude mice xenografted with A549, RKO (colorectal carcinoma), and HeLa cells.
  • 同义词
    Apoptozole | Apoptosis Activator VII
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    HSC70| HSP70
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1054543-47-3
  • 分子量
    625.56
  • 分子式
    C33H25F6N3O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 31 mg/mL; 49.56 mM
  • SMILES
    COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC
  • 化学全称
    4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Ko SK, et al. Chem Biol. 2015 Mar 19;22(3):391-403.
产品手册
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