Apoptozole ( Apoptozole; Apoptosis Activator VII )

产品货号. M17785 CAS No. 1054543-47-3

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Apoptozole
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.
产品描述

Apoptozole, also known as Apoptosis Activator VII, is a selective inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. Apoptozole enhances immune responses to administered antigens. Treatment of mice with Apoptozole elicits production of antibodies with a high IgG2c/IgG1 ratio and stimulates the release of Th1 and Th2-type cytokines, suggesting that Apoptozole activates the Th1 and Th2 immune responses. The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes.
同义词

Apoptozole; Apoptosis Activator VII
通路

Others
靶点

Other Targets
受体

HSC70; HSP70
研究领域

Cancer
适应症

——

CAS Number

1054543-47-3
分子量

625.56
分子式

C33H25F6N3O3
纯度

98%
溶解度

DMSO : ≥ 31 mg/mL; 49.56 mM
SMILES

COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC
化学全称

4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide

1. Ko SK, et al. Chem Biol. 2015 Mar 19;22(3):391-403.

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