Apigenin-7-glucuronide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Apigenin-7-glucuronide 具有多种活性，包括抗氧化、抗炎和醛糖还原酶抑制活性，它可以抑制 MMP 活性（对于 MMP-3、MMP-8、MMP-9，IC50 值：12.87、22.39、17.52、0.27 μM） ，MMP-13，分别）。

Apigenin-7-glucuronide possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s: 12.87 22.39 17.52 0.27 μM for MMP-3 MMP-8 MMP-9 MMP-13 respectively).(In Vitro):Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively . Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups.

Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively . Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups.

——

Apigenin 7-O-glucuronide

Metabolic Enzyme/Protease

MMP

MMP-3| MMP-8|MMP-13| MMP-9

——

——

29741-09-1

446.36

C21H18O11

>98% (HPLC)

DMSO: 50 mg/mL (112.02 mM)

O[C@H]1[C@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years