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Amelubant
CAS No. 346735-24-8
Amelubant ( BIIL284 | BIIL-284 )
产品货号. M14191 CAS No. 346735-24-8
Amelubant (BIIL284) 是一种有效、长效、口服活性的白三烯 B4 (LTB4) 受体拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Amelubant
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Amelubant (BIIL284) 是一种有效、长效、口服活性的白三烯 B4 (LTB4) 受体拮抗剂。
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产品描述Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist, inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.); inhibits LTB(4)-induced transdermal chemotaxis in guinea pigs with ED50 of 0.03 mg/kg p.o.Rheumatoid Arthritis Phase 2 Discontinued.
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体外实验Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively.
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体内实验——
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同义词BIIL284 | BIIL-284
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通路GPCR/G Protein
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靶点Leukotriene Receptor
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受体Leukotriene Receptor
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研究领域Inflammation/Immunology
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适应症Rheumatoid Arthritis
化学信息
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CAS Number346735-24-8
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分子量538.644
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分子式C33H34N2O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (185.66 mM)
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SMILESO=C(OCC)N/C=N/C1=CC=C(OCC2=CC=CC(COC3=CC=C(C(C)(C4=CC=C(O)C=C4)C)C=C3)=C2)C=C1
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化学全称ethyl (Z)-(amino(4-((3-((4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)methyl)benzyl)oxy)phenyl)methylene)carbamate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Birke FW, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.
2. D?ring G, et al. J Cyst Fibros. 2014 Mar;13(2):156-63.
产品手册
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