Alogliptin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Alogliptin(SYR-322) 是一种有效的选择性 DPP-4 抑制剂，IC50 <10 nM，选择性比 DPP-8 和 DPP-9 高 10, 000 倍。

Alogliptin is a DPP-4 inhibitor used for the treatment of Type 2 diabetes. Like other members of the gliptin class, it causes little or no weight gain, exhibits relatively little risk of causing hypoglycemia, and exhibits relatively modest glucose-lowering activity. Alogliptin and other gliptins are commonly used in combination with metformin in patients whose diabetes cannot adequately be controlled with metformin alone.

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Alogliptin

Chromatin/Epigenetic

Sirtuin

DPP-4

Metabolic Disease

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850649-61-5

339.39

C18H21N5O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (294.65 mM)

CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=CC=CC=C2C#N)C1=O

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile

(-20℃)

With Ice Pack

≥ 2 years