Ajmalicine ( Raubasine | Delta-Yohimbine | Ajmalicin | Lamuran )

产品货号. M28573 CAS No. 483-04-5

Ajmalicine (Raubasine) 是一种有效的肾上腺素分解剂，可优先阻断 α1-肾上腺素受体。 Ajmalicine 是一种可逆但非竞争性尼古丁受体完全抑制剂，IC50 = 72.3 μM。 Ajmalicine 还可用作抗高血压药，而蛇纹石则具有镇静活性。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥1361	有现货
5MG	￥2292	有现货
10MG	￥3418	有现货
25MG	￥5573	有现货
50MG	￥7752	有现货
100MG	￥10449	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Ajmalicine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Ajmalicine (Raubasine) 是一种有效的肾上腺素分解剂，可优先阻断 α1-肾上腺素受体。 Ajmalicine 是一种可逆但非竞争性尼古丁受体完全抑制剂，IC50 = 72.3 μM。 Ajmalicine 还可用作抗高血压药，而蛇纹石则具有镇静活性。
产品描述

Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。(In Vitro):Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor. Ajmalicine inhibits contractions in a concentration-dependent manner, IC50=72.3 ± 22.5 μM. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.(In Vivo):Ajmalicine blocks the pressor action of electrical stimulation and is active against sympathetic stimulation. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline.
体外实验

Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor.Ajmalicine inhibits contractions in a concentration-dependent manner (IC50=72.3 ± 22.5 μM).Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.
体内实验

Ajmalicine blocking the pressor action of electrical stimulation and is active against sympathetic stimulation.Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline. Animal Model:Male Wistar rats (300-350 g)Dosage:0.5, 1, 2, and 4 mg/kg Administration:IV, once Result:Induced a marked dose-dependent inhibition against the pressor response to noradrenaline.
同义词

Raubasine | Delta-Yohimbine | Ajmalicin | Lamuran
通路

Angiogenesis
靶点

Adrenergic Receptor
受体

p53
研究领域

——
适应症

——

化学信息

CAS Number

483-04-5
分子量

352.43
分子式

C21H24N2O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 5.56 mg/mL (15.78 mM)
SMILES

[H][C@@]12C[C@]3([H])C(=CO[C@@H](C)[C@@]3([H])CN1CCc1c2[nH]c2ccccc12)C(=O)OC
化学全称

——