Adoprazine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Adoprazine 是一种潜在的非典型抗精神病药，具有有效的 D2 受体拮抗剂和 5-HT1A 受体激动剂特性。

Adoprazine is a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.

Adoprazine (SLV313) has high affinity at human recombinant D2, D3, D4, 5-HT2B, and 5-HT1A receptors, with pKis of 8.4, 8.4, 8.0, 7.9 and 9.1, respectively. Adoprazine (SLV313) acts as a high potency dopamine D2 receptor antagonist and an efficacious serotonin 5-HT1A receptor agonist, with Emax value (% effect of 10 μM 5-HT) of 73 and pKB value of 8.5 .

Adoprazine (SLV313) (0.1-10 mg/kg; p.o.; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner. Animal Model:Male Wistar rats (275-350 g) Dosage:0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg Administration:p.o.; single Result:Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels.

SLV313

Others

Other Targets

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222551-17-9

405.473

C24H24FN3O2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (123.32 mM)

Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2cccc3OCCOc23)c1

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(-20℃)

With Ice Pack

≥ 2 years