AZD5904

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZD5904 (AZD-5904) 是一种有效的、选择性不可逆的、口服生物可利用的髓过氧化物酶 (MPO) 抑制剂，IC50 为 140 nM。

AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat; displays 10 to 19-fold selective compared to the closely related lactoperoxidase and thyroid peroxidase, >70-fold to a broad panel of other enzymes, ion channels, and receptors; 1 μM AZD5904 inhibited PMA stimulated HOCl by >90% in isolated human neutrophils; a plasma concentration of ~5 μM decreased the in vivo formation of glutathione sulphonamide in rats.Multiple Sclerosis Phase 1 Discontinued.

——

——

AZD 5904 | AZD-5904

Others

Other Targets

Other Targets

Inflammation/Immunology

Multiple Sclerosis

618913-30-7

252.292

C10H12N4O2S

>98% (HPLC)

DMSO : 125 mg/mL 495.46 mM

O=C1NC(N(C[C@H]2OCCC2)C3=C1NC=N3)=S

6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- (9CI)

(-20℃)

With Ice Pack

≥ 2 years