AZD5904 ( AZD 5904 | AZD-5904 )

产品货号. M15342 CAS No. 618913-30-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AZD5904
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AZD5904 (AZD-5904) 是一种有效的、选择性不可逆的、口服生物可利用的髓过氧化物酶 (MPO) 抑制剂，IC50 为 140 nM。
产品描述

AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat; displays 10 to 19-fold selective compared to the closely related lactoperoxidase and thyroid peroxidase, >70-fold to a broad panel of other enzymes, ion channels, and receptors; 1 μM AZD5904 inhibited PMA stimulated HOCl by >90% in isolated human neutrophils; a plasma concentration of ~5 μM decreased the in vivo formation of glutathione sulphonamide in rats.Multiple Sclerosis Phase 1 Discontinued.
体外实验

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体内实验

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同义词

AZD 5904 | AZD-5904
通路

Others
靶点

Other Targets
受体

Other Targets
研究领域

Inflammation/Immunology
适应症

Multiple Sclerosis

CAS Number

618913-30-7
分子量

252.292
分子式

C10H12N4O2S
纯度

>98% (HPLC)
溶解度

DMSO : 125 mg/mL 495.46 mM
SMILES

O=C1NC(N(C[C@H]2OCCC2)C3=C1NC=N3)=S
化学全称

6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- (9CI)

计算器

产品手册

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