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AZD5423
CAS No. 1034148-04-3
AZD5423 ( —— )
产品货号. M23241 CAS No. 1034148-04-3
AZD5423 是一种吸入性、强效、选择性、非甾体类糖皮质激素受体 (GR) 调节剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥478 | 有现货 |
|
| 5MG | ￥786 | 有现货 |
|
| 10MG | ￥1320 | 有现货 |
|
| 25MG | ￥2406 | 有现货 |
|
| 50MG | ￥4277 | 有现货 |
|
| 100MG | ￥6229 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AZD5423
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AZD5423 是一种吸入性、强效、选择性、非甾体类糖皮质激素受体 (GR) 调节剂。
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产品描述AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.
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体外实验The affinity of AZD5423 to the glucocorticoid receptor is high with an IC50 of 0.9 nM in a radioligand human glucocorticoid receptor assay, and selectivity towards other steroid hormone receptors is >900-fold.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Glucocorticoid receptor
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研究领域——
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适应症——
化学信息
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CAS Number1034148-04-3
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分子量487.45
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分子式C25H21F4N3O3
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (205.15 mM; Need ultrasonic)
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SMILESO=C(N[C@@H](C)[C@H](OC1=CC2=C(N(C3=CC=C(F)C=C3)N=C2)C=C1)C4=CC=CC(OC)=C4)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Werkstr?m V, et al. Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator AZD5423 after Inhalation in Healthy Volunteers. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581.
产品手册
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