
AZD-26
CAS No. 1357158-81-6
AZD-26 ( AZD-26 | AZD 26 | AZD26 )
产品货号. M17970 CAS No. 1357158-81-6
AZD-26 是一种变构 AKT 抑制剂 (IC50: 1.04 μM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1304 | 有现货 |
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5MG | ¥2001 | 有现货 |
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10MG | ¥3418 | 有现货 |
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25MG | ¥5565 | 有现货 |
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50MG | ¥7752 | 有现货 |
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100MG | ¥10449 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称AZD-26
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述AZD-26 是一种变构 AKT 抑制剂 (IC50: 1.04 μM)。
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产品描述AZD-26 is an inhibitor of AKT.
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体外实验AKT-IN-1 is able to potently inhibit phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM, respectively. AKT-IN-1 inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway. AKT-IN-1 potently inhibits the phosphorylation of PRAS40.
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体内实验The effects of AKT-IN-1 (Compound 26) in vivo are characterized by measuring the pharmacodynamic activity of AKT-IN-1 in a BT474c breast adenocarcinoma xenograft model. Following acute doses of 100 and 200 mg/kg, AKT-IN-1 potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473), with a potency consistent with its pharmacokinetic profile. The in vivo activity of AKT-IN-1 is further characterized by measuring the effects on the growth of tumor cell xenografts. Continuous (daily) oral dosing of AKT-IN-1 (100 and 200 mg/kg) to nude mice bearing BT474c breast adenocarcinoma xenografts results in inhibition of tumor growth in a dose-dependent manner. When dosed at 200 mg/kg daily, AKT-IN-1 causes significant tumor growth inhibition.
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同义词AZD-26 | AZD 26 | AZD26
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通路Others
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靶点Other Targets
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受体allosteric Akt
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研究领域——
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适应症——
化学信息
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CAS Number1357158-81-6
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分子量343.42
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分子式C22H21N3O
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纯度>98% (HPLC)
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溶解度DMSO : 25 mg/mL 72.80 mM;
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SMILESNC1(CCC1)c2ccc(cc2)c3ncc(cc3c4ccccc4)C(N)=O
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化学全称6-[4-(1-Aminocyclobutyl)phenyl]-5-phenylpyridine-3-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kettle JG, et al. Diverse heterocyclic scaffolds as allosteric inhibitors of AKT. J Med Chem. 2012 Feb 9;55(3):1261-73.
产品手册




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