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AZ12601011
CAS No. ——
AZ12601011 ( AZ-12601011 | AZ 12601011 )
产品货号. M16993 CAS No. ——
AZ12601011 (AZ-12601011) 是一种有效的选择性 ALK4、ALK7 和 TGFBR1 抑制剂 (Kd=2.9 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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生物学信息
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产品名称AZ12601011
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AZ12601011 (AZ-12601011) 是一种有效的选择性 ALK4、ALK7 和 TGFBR1 抑制剂 (Kd=2.9 nM)。
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产品描述AZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM), inhibits TGFβ-induced reporter activity with IC50 of 18 nM; inhibits TGFBR1 kinase activity (competition binding) with Kd of 2.9 nM, shows some inhibitory activity against the related receptors ALK4 and BMPR1B, but shows only weakly activity against ALK1, ALK2 and BMPR1A in in vitro kinase assays; AZ12601011 is a more effective inhibitor of TGFβ-induced reporter activity than SB-431542 (IC50=84nM) and LY2157299 (galunisertib) (IC50=380nM), inhibits phosphorylation of SMAD2 via the type 1 receptors ALK4, TGFBR1 and ALK7; AZ12601011 is highly effective at inhibiting basal and TGFβ-induced migration of HaCaT keratinocytes, inhibits tumour growth and metastasis to the lungs in a 4T1 syngeneic orthotopic mammary tumour model.
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体外实验——
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体内实验——
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同义词AZ-12601011 | AZ 12601011
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通路TGF-beta/Smad
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靶点TGFBR
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受体TGFBR
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量313.364
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分子式C19H15N5
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Spender LC, et al. Mol Pharmacol. 2018 Nov 20. pii: mol.118.112946. doi: 10.1124/mol.118.112946.
