AUNP-12

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AUNP-12 (Aurigene-012) 是一种 PD-1 抑制剂肽。

AUNP-12 (Aurigene-012) is a PD-1 inhibitor peptide, blocks the PD-1/PD-L1, PD-1/PD-L2 and PD-L1/CD80 pathways; AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses.

AUNP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions .AUNP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively.AUNP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively.

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Aurigene-012 | AUR 012

Immunology/Inflammation

PD-1/PD-L1

PD-1/PD-L1

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1353563-85-5

3261.55

C142H226N40O48

>98% (HPLC)

In Vitro:?H2O : 10 mg/mL (3.07 mM助溶)

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(-20℃)

With Ice Pack

≥ 2 years