
AUDA
CAS No. 479413-70-2
AUDA ( —— )
产品货号. M21149 CAS No. 479413-70-2
AUDA 是 sEH 的抑制剂(对小鼠和人类酶的 IC50 值分别为 18 和 69 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥365 | 有现货 |
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25MG | ¥810 | 有现货 |
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50MG | ¥1474 | 有现货 |
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100MG | ¥2624 | 有现货 |
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200MG | ¥3410 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称AUDA
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述AUDA 是 sEH 的抑制剂(对小鼠和人类酶的 IC50 值分别为 18 和 69 nM)。
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产品描述AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes respectively).
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体外实验AUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF. AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression. AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner. AUDA significantly increases the adhesion ability of HCAECs. Cell Proliferation AssayCell Line:Vascular smooth muscle cell (VSMC)Concentration:0.3, 1, 3, 10 μg/mLIncubation Time:48 hoursResult:Dose-dependently suppressed the proliferation of rat VSMCs exposed to PDGF. Western Blot AnalysisCell Line:VSMC Concentration:1, 3, 10, 30 μg/mL Incubation Time:30 minResult:Dose-dependently upregulated COX-2 expression.
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体内实验AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels. Animal Model:Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g) Dosage:10 mg/kg Administration:i.p.; 14 days Result:Reduced TNF-α, MMP-9 and IL-1β expression levels.
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同义词——
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通路Others
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靶点Other Targets
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受体sEH
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研究领域——
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适应症——
化学信息
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CAS Number479413-70-2
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分子量392.6
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分子式C23H40N2O3
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纯度>98% (HPLC)
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溶解度DMSO:1mg/ml(2.55mM)
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SMILESO=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2
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化学全称12-[(Adamantan-1-ylcarbamoyl)amino]dodecanoic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Hyo K Sang K Keon K . Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells[J]. International Journal of Molecular Sciences 2017 18(12):2683-.
产品手册




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