
AT-56
CAS No. 162640-98-4
AT-56 ( AT-56 | AT 56 | AT56 )
产品货号. M12406 CAS No. 162640-98-4
AT56 是前列腺素 D2 合酶酶活性的特异性抑制剂,可减弱醛固酮的脂肪形成作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥616 | 有现货 |
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10MG | ¥1037 | 有现货 |
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25MG | ¥2041 | 有现货 |
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50MG | ¥3686 | 有现货 |
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100MG | ¥5443 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称AT-56
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述AT56 是前列腺素 D2 合酶酶活性的特异性抑制剂,可减弱醛固酮的脂肪形成作用。
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产品描述AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.
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体外实验AT-56 (1-30 μM; 10 minutes) dose-dependently inhibits the production of PGD2 in L-PGDS-expressing human medulloblastoma TE-671 cells with an IC50 of about 3 μM.
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体内实验AT-56 (?1-30 mg/kg; p.o.) suppresses the PGD2 production in the stab-wounded brain.AT-56 (1-10 mg/kg; p.o.) suppresses the L-PGDS-mediated allergic airway inflammation in mice.AT-56 (10 mg/kg; p.o.) exhibits Cmax (2.15 μg/ml), half-life (1.71 h) and high oral bioavailability (82%). Animal Model:H-PGDS KO mice (14-16weeks, 25-30 g, C57BL/6 strain) with a stab wound brain injuryDosage:0, 1, 3, 10, 30?mg/kg Administration:P.o. 1 h before the stab wound injury Result:Inhibited the L-PGDS reaction in the brain.Decreased the total amount of PGD2 in the brain to 40% with 30 mg/kg AT-56.Animal Model:Human L-PGDS-overexpressing TG mice (males, 14-16 weeks, 25-30 g)Dosage:?0, 1, 10 mg/kg Administration:P.o. 1 h before and 24 h after the antigen exposure Result:Prevented the eosinophil infiltration by inhibiting transgened human L-PGDS.Animal Model:Male C57BL/6 mice (7 weeks, 22-26 g) Dosage:10?mg/kg for p.o. and 2 mg/kg for i.v. (Pharmacokinetic Analysis)Administration:P.o. and i.v. administration Result:Oral bioavailability (82%); Cmax (2.15 μg/ml); T1/2 (1.71 h, p.o.); T1/2 (2.35 h, i.v.).
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同义词AT-56 | AT 56 | AT56
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通路Others
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靶点Other Targets
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受体L-PGDS
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研究领域——
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适应症——
化学信息
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CAS Number162640-98-4
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分子量397.52
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分子式C25H27N5
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纯度>98% (HPLC)
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溶解度DMSO: > 10 mM
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SMILESN1(CCCCC2=NNN=N2)CC/C(CC1)=C3C4=CC=CC=C4C=CC5=CC=CC=C/35
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化学全称4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Urbanet R, et al. Hypertension. 2015 Jul;66(1):149-57.
产品手册




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