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ASK1-IN-1
CAS No. 2411382-24-4
ASK1-IN-1 ( —— )
产品货号. M28839 CAS No. 2411382-24-4
ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1831 | 有现货 |
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| 10MG | ￥3216 | 有现货 |
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| 25MG | ￥5549 | 有现货 |
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| 50MG | ￥7898 | 有现货 |
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| 100MG | ￥10692 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ASK1-IN-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.
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产品描述ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.(In Vitro):ASK1-IN-1 shows good potency with cell IC50 of 138 nM. ASK1-IN-1 has superior CYP inhibition profile.(In Vivo):ASK1-IN-1 shows low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC50/IC70/IC90 at trough in the brain for 12 hours of 50/115/435 mg/kg respectively.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number2411382-24-4
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分子量405.4
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分子式C19H19N9O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)n1c(-c2cccc(NC(c3cn(-c4nccnc4)nc3OC)=O)n2)nnc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Fan JY, et al. A systematic review of the botanical, phytochemical and pharmacological profile of Dracaena cochinchinensis, a plant source of the ethnomedicine "dragon's blood". Molecules. 2014;19(7):10650-10669. Published 2014 Jul 22.
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