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AS101

CAS No. 106566-58-9

AS101 ( AS-101 | IVX-Q-101 | PRX-0001 )

产品货号. M17134 CAS No. 106566-58-9

AS101 是一种有效的体外和体内免疫调节剂,是一种新型的 IL-1beta 转换酶抑制剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥640 有现货
10MG ¥988 有现货
25MG ¥1555 有现货
50MG ¥2373 有现货
100MG ¥3572 有现货
200MG ¥5257 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    AS101
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    AS101 是一种有效的体外和体内免疫调节剂,是一种新型的 IL-1beta 转换酶抑制剂。
  • 产品描述
    AS101, also known as Ossirene, is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. Ammonium trichlorotellurate may inhibit the inflammatory cytokine interleukin-10 (IL-10) and may induce hematopoietic cells to express interleukin-2 (IL-2), IL-2 receptors, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, tumor necrosis factor (TNF) and interferons (INFs). This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced myelosuppression. In addition, this agent exhibits hair growth-promoting activity by inducing anagen production and inhibiting catagen production, resulting in the promotion of follicular keratinocyte proliferation and interference with follicular keratinocyte terminal differentiation, respectively. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia.(In Vitro):Ossirene (AS101; 1 μg/mL; for 24 hours) almost completely abrogates expression of pStat3. Ossirene may reduce expression of Bcl-2 after inhibition of Stat3 activation via IL-10 inhibition.AS101 (0.5, 5 mg/mL; 24 hours) inhibits IL-1β-induced mRNA expression of inflammatory mediators in the RPE in a dose-dependent manner. AS101 inhibits IL-1β-induced mRNA expression and protein production of IL-6 and IL-8 in RPE cells. AS101 (5 mg/mL; 1 hour) inhibits the phosphorylation of the p65 component of the NFκB complex activated by IL-1β.Ossirene (0.1, 0.5, 1, 2.5 μg/mL) significantly decreases B16 melanoma, stomach adenocarcinoma, and human glioblastoma multiforme (GBM) cells proliferation.AS101 (0.5 μg/mL; for 24 hours) sensitizes GBM tumor cells to paclitaxel in an IL-10-dependent manner.(In Vivo):Ossirene (AS101; 0.5 mg/kg/day; IP; 25 days) sensitizes GBM tumors to paclitaxel via inhibition of IL-10, resulting in increased survival.
  • 体外实验
    Ossirene (AS101; 1 μg/mL; for 24 hours) almost completely abrogates expression of pStat3. Ossirene may reduce expression of Bcl-2 after inhibition of Stat3 activation via IL-10 inhibition. AS101 (0.5, 5 mg/mL; 24 hours) inhibits IL-1β-induced mRNA expression of inflammatory mediators in the RPE in a dose-dependent manner. AS101 inhibits IL-1β-induced mRNA expression and protein production of IL-6 and IL-8 in RPE cells. AS101 (5 mg/mL; 1 hour) inhibits the phosphorylation of the p65 component of the NFκB complex activated by IL-1β. Ossirene (0.1, 0.5, 1, 2.5 μg/mL) significantly decreases B16 melanoma, stomach adenocarcinoma, and human glioblastoma multiforme (GBM) cells proliferation. AS101 (0.5 μg/mL; for 24 hours) sensitizes GBM tumor cells to paclitaxel in an IL-10-dependent manner. Western Blot Analysis Cell Line:B16 melanoma cells Concentration:1 μg/mL Incubation Time:For 24 hours Result:Almost completely abrogated expression of pStat3. RT-PCR Cell Line:ARPE19 cells Concentration:0.5, 5 mg/mL Incubation Time:24 hours Result:Inhibited IL-1β-induced mRNA expression of inflammatory mediators in the RPE in a dose-dependent manner.
  • 体内实验
    Ossirene (AS101; 0.5 mg/kg/day; IP; 25 days) sensitizes GBM tumors to paclitaxel via inhibition of IL-10, resulting in increased survival. Animal Model:SCID mice with GBM cellsDosage:0.5 mg/kg Administration:IP; daily; 25 days Result:Significantly increased survival of GBM tumor-bearing mice.
  • 同义词
    AS-101 | IVX-Q-101 | PRX-0001
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    IL-1β converting enzyme
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    106566-58-9
  • 分子量
    312.05
  • 分子式
    C2H4Cl3O2Te·H4N
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 12.5 mg/mL (40.06 mM)
  • SMILES
    C1CO[Te](O1)(Cl)(Cl)Cl.[NH4+]
  • 化学全称
    Ammonium trichloro(dioxoethylene-O,O') tellurate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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