AS057278

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AS057278 是一种 D-氨基酸氧化酶 (DAAO) 抑制剂。

AS057278 is an D-amino acid oxidase (DAAO) inhibitor.

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AS057278 (PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage) normalizes?phencyclidine?(PCP)-induced?prepulse inhibition.AS057278 (10 mg/kg; PO and IV; single dosage) exhibits good pharmacokinetic effects.Pharmacokinetic Parameters of AS057278 in male Sprague-Dawley rats. Animal Model:Males C57BL/6J miceDosage:80 mg/kg, 20 mg/kg Administration:PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage Result:Normalized?phencyclidine?(PCP)-induced?prepulse inhibition?after acute (80?mg/kg) and chronic (20?mg/kg b.i.d.)?oral administration?in mice.Animal Model:Male Sprague-Dawley ratsDosage:10 mg/kg Administration:PO and IV; single dosage (Pharmacokinetics Analysis)Result:Exhibited good pharmacokinetic effect.

3-Methylpyrazole-5-carboxylic acid

Others

Other Targets

D-amino acid oxidase (DAAO)

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402-61-9

126.11

C5H6N2O2

>98% (HPLC)

DMSO:25mg/mL(198.24mM)

Cc1cc(C(=O)O)n[nH]1

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(-20℃)

With Ice Pack

≥ 2 years