AS-604850 ( AS604850; AS 604850; AS-604850 )

产品货号. M17562 CAS No. 648449-76-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AS-604850
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AS-604850 is a specific and ATP-competitive PI3Kγ inhibitor (IC50: 250 nM), 18-fold more selective for PI3Kγ than PI3Kα, and over 80-fold selectivity for PI3Kγ than PI3Kδ/β.
产品描述

AS-604850 is a selective PI3Kγ inhibitor, which significantly reduced the number of infiltrated leukocytes in the CNS and ameliorated the clinical symptoms of EAE mice. Treatment with this PI3Kγ inhibitor enhanced myelination and axon number in the spinal cord of EAE mice. PI3Kγ contributes to development of autoimmune CNS inflammation and that PI3Kγ blockade may provide a great potential for treating patients with MS.
同义词

AS604850; AS 604850; AS-604850
通路

Others
靶点

Other Targets
受体

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
研究领域

Inflammation/Immunology
适应症

——

CAS Number

648449-76-7
分子量

285.22
分子式

C11H5F2NO4S
纯度

98%
溶解度

——
SMILES

c1cc2c(cc1/C=C\1/C(=O)NC(=O)S1)OC(O2)(F)F
化学全称

(Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione

1. Camps M, et al, Nat Med, 2005, 11(9), 936-943.

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