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AS-604850

CAS No. 648449-76-7

AS-604850 ( AS604850; AS 604850; AS-604850 )

产品货号. M17562 CAS No. 648449-76-7

AS-604850 is a specific and ATP-competitive PI3Kγ inhibitor (IC50: 250 nM), 18-fold more selective for PI3Kγ than PI3Kα, and over 80-fold selectivity for PI3Kγ than PI3Kδ/β.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥316 有现货
10MG ¥583 有现货
25MG ¥988 有现货
50MG ¥1604 有现货
100MG ¥2989 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    AS-604850
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    AS-604850 is a specific and ATP-competitive PI3Kγ inhibitor (IC50: 250 nM), 18-fold more selective for PI3Kγ than PI3Kα, and over 80-fold selectivity for PI3Kγ than PI3Kδ/β.
  • 产品描述
    AS-604850 is a selective PI3Kγ inhibitor, which significantly reduced the number of infiltrated leukocytes in the CNS and ameliorated the clinical symptoms of EAE mice. Treatment with this PI3Kγ inhibitor enhanced myelination and axon number in the spinal cord of EAE mice. PI3Kγ contributes to development of autoimmune CNS inflammation and that PI3Kγ blockade may provide a great potential for treating patients with MS.
  • 同义词
    AS604850; AS 604850; AS-604850
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  • 研究领域
    Inflammation/Immunology
  • 适应症
    ——

化学信息

  • CAS Number
    648449-76-7
  • 分子量
    285.22
  • 分子式
    C11H5F2NO4S
  • 纯度
    98%
  • 溶解度
    ——
  • SMILES
    c1cc2c(cc1/C=C\1/C(=O)NC(=O)S1)OC(O2)(F)F
  • 化学全称
    (Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Camps M, et al, Nat Med, 2005, 11(9), 936-943.
产品手册
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