ARN14974

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ARN14974 是一种苯并恶唑酮甲酰胺。 ARN14974 是一种有效的酸性神经酰胺酶抑制剂，IC50 为 79 nM。

ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM.

ARN14974 (20 μM; 24 hours;SW403 and Raw 264.7 cells) inhibits acid ceramidase (AC) in a complex cellular environment, leading to the intended biochemical response, that is, increased ceramide and decreased sphingosine levels.

ARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney.ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, Cmax, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a Cmax and a half-life time of 628 ng/mL and 72 min, respectively.

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Others

Other Targets

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1644158-57-5

404.441

C24H21FN2O3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (123.63 mM)

Fc1ccc(cc1)-c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1

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(-20℃)

With Ice Pack

≥ 2 years