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APR-246
CAS No. 5291-32-7
APR-246 ( PRIMA-1MET )
产品货号. M14875 CAS No. 5291-32-7
APR-246 (PRIMA-1MET) 是 PRIMA-1 的甲基化衍生物，可恢复突变型 p53 活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥543 | 有现货 |
|
| 10MG | ￥867 | 有现货 |
|
| 25MG | ￥1758 | 有现货 |
|
| 50MG | ￥3135 | 有现货 |
|
| 100MG | ￥5565 | 有现货 |
|
| 500MG | ￥11259 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称APR-246
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述APR-246 (PRIMA-1MET) 是 PRIMA-1 的甲基化衍生物，可恢复突变型 p53 活性。
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产品描述APR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation; also restores the pro-apoptotic function to mutant TAp63γ and TAp73β in tumor cells but has less effect on TAp73α;induces mutant p53-dependent mitochondria-mediated apoptosis through activation of caspase-2 with subsequent cytochrome c release and further activation of downstream caspase-9 and caspase-3; inhibits tumor xenograft growth in vivo.Ovarian Cancer Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词PRIMA-1MET
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通路Apoptosis
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靶点MDM2-p53
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受体p53activator|TrxR1inhibitor
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研究领域Cancer
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适应症Ovarian Cancer
化学信息
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CAS Number5291-32-7
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分子量199.25
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分子式C10H17NO3
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纯度>98% (HPLC)
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溶解度DMSO: 20mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C1C(COC)(CO)N2CCC1CC2
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化学全称2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Shen J, et al. Oncogene. 2008 Nov 20;27(51):6571-80.
2. Bykov VJ, et al. Oncogene. 2005 May 12;24(21):3484-91.
3. R?kaeus N, et al. Oncogene. 2010 Dec 9;29(49):6442-51.
