AP20187
CAS No. 195514-80-8
AP20187 ( B/B Homodimerizer )
产品货号. M26606 CAS No. 195514-80-8
AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins. And it initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2130 | 有现货 |
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10MG | ¥3345 | 有现货 |
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25MG | ¥5605 | 有现货 |
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50MG | ¥7979 | 有现货 |
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100MG | ¥10773 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AP20187
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins. And it initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
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产品描述AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins. And it initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.(In Vitro):When LNCaP cells are treated with AP20187 (B/B Homodimerizer) (100 nM), ro-iCaspase-9 levels are significantly reduced. However the smaller processed active caspase-9 becomes apparent.(In Vivo):AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice. AP20187 (B/B Homodimerizer) treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mice. Real-time PCR analysis shows that AP20187 (B/B Homodimerizer) (0.5 mg/kg, 2 mg/kg, or 5 mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mice at PID12.
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同义词B/B Homodimerizer
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通路Others
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靶点Other Targets
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受体Angiotensin Receptor; NO
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研究领域——
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适应症——
化学信息
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CAS Number195514-80-8
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分子量1482.8
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分子式C82H107N5O20
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纯度>98% (HPLC)
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溶解度——
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SMILESCC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(=O)NCC(CNC(=O)COc2cccc(c2)[C@@H](CCc2ccc(OC)c(OC)c2)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC)c2cc(OC)c(OC)c(OC)c2)CN(C)C)c1)c1cc(OC)c(OC)c(OC)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Marie-Lynda Bouressam, et al. S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT 1 receptor responses: A possible role of S-nitrosation. Br J Pharmacol. 2019 Jun;176(12):2049-2062.
产品手册
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