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AP1903
CAS No. 195514-63-7
AP1903 ( Rimiducid | AP-1903 )
产品货号. M13061 CAS No. 195514-63-7
AP1903 (Rimiducid, AP-1903) 是 FKBP Phe36Val 突变体 (F36V-FKBP) 的有效、特异性合成配体，结合 IC50 为 1.8 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1596 | 有现货 |
|
| 5MG | ￥2568 | 有现货 |
|
| 10MG | ￥3783 | 有现货 |
|
| 25MG | ￥6221 | 有现货 |
|
| 50MG | ￥8748 | 有现货 |
|
| 100MG | ￥11745 | 有现货 |
|
| 500MG | ￥23409 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AP1903
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AP1903 (Rimiducid, AP-1903) 是 FKBP Phe36Val 突变体 (F36V-FKBP) 的有效、特异性合成配体，结合 IC50 为 1.8 nM。
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产品描述AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM; displaces the Fluoresceinated FK506 probe from F36V-FKBP with an IC50 of 5 nM, but shows negligible binding activity to the wild-type protein; elicited potent and dose-dependent apoptotic death of human fibrosarcoma line HT1080 expressing dimerizer-dependent Fas constructs with EC50 of 0.1 nM; induces activation of Fas signaling both in vitro and in vivo, AP1903 is a lipid-permeant dimerizing ligand induced oligomerization and activation of FKBP.Blood Cancer Phase 3 Clinical
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体外实验——
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体内实验——
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同义词Rimiducid | AP-1903
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number195514-63-7
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分子量1411.65
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分子式C78H98N4O20
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 54 mg/mL 38.25 mM
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SMILESO=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCC(NCCNC(COC4=CC=CC([C@H](OC([C@H]5N(C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)CCCC5)=O)CCC7=CC=C(OC)C(OC)=C7)=C4)=O)=O)=C3)CCC8=CC=C(OC)C(OC)=C8
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化学全称(S,2R,2'R)-(1R,1'R)-((((ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Clackson T, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.
2. Richard RE, et al. Blood. 2000 Jan 15;95(2):430-6.
3. Thomis DC, et al. Blood. 2001 Mar 1;97(5):1249-57.
4. Narayanan P, et al. J Clin Invest. 2011 Apr;121(4):1524-34.
产品手册
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