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首页- Products - Others - Other Targets - AP1903

AP1903

CAS No. 195514-63-7

AP1903 ( Rimiducid;AP-1903 )

产品货号. M13061 CAS No. 195514-63-7

AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ￥1596 有现货
5MG ￥2568 有现货
10MG ￥3783 有现货
25MG ￥6221 有现货
50MG ￥8748 有现货
100MG ￥11745 有现货
500MG ￥23409 有现货
1G 获取报价 有现货
拼团 产品询价 大包装询价 加入购物车

生物学信息

  • 产品名称
    AP1903
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
  • 产品描述
    AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM; displaces the Fluoresceinated FK506 probe from F36V-FKBP with an IC50 of 5 nM, but shows negligible binding activity to the wild-type protein; elicited potent and dose-dependent apoptotic death of human fibrosarcoma line HT1080 expressing dimerizer-dependent Fas constructs with EC50 of 0.1 nM; induces activation of Fas signaling both in vitro and in vivo, AP1903 is a lipid-permeant dimerizing ligand induced oligomerization and activation of FKBP.Blood Cancer Phase 3 Clinical
  • 同义词
    Rimiducid;AP-1903
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Other Targets
  • 研究领域
    Cancer
  • 适应症
    Blood cancer

化学信息

  • CAS Number
    195514-63-7
  • 分子量
    1411.65
  • 分子式
    C78H98N4O20
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 54 mg/mL 38.25 mM
  • SMILES
    O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCC(NCCNC(COC4=CC=CC([C@H](OC([C@H]5N(C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)CCCC5)=O)CCC7=CC=C(OC)C(OC)=C7)=C4)=O)=O)=C3)CCC8=CC=C(OC)C(OC)=C8
  • 化学全称
    (S,2R,2'R)-(1R,1'R)-((((ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Clackson T, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.
2. Richard RE, et al. Blood. 2000 Jan 15;95(2):430-6.
3. Thomis DC, et al. Blood. 2001 Mar 1;97(5):1249-57.
4. Narayanan P, et al. J Clin Invest. 2011 Apr;121(4):1524-34.
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