AM966
CAS No. 1228690-19-4
AM966 ( AM-966; AM 966; AM966 )
产品货号. M17206 CAS No. 1228690-19-4
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥275 | 有现货 |
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5MG | ¥446 | 有现货 |
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10MG | ¥721 | 有现货 |
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25MG | ¥1320 | 有现货 |
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50MG | ¥2252 | 有现货 |
|
100MG | ¥3621 | 有现货 |
|
500MG | ¥8084 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AM966
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
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产品描述AM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model.Last. In vitro, AM966 inhibited LPA-stimulated intracellular calcium release (IC(50)= 17 nM) from Chinese hamster ovary cells stably expressing human LPA(1) receptors and inhibited LPA-induced chemotaxis (IC(50)= 181 nM) of human IMR-90 lung fibroblasts expressing LPA(1) receptors. AM966 demonstrated a good pharmacokinetic profile following oral dosing in mice. In the mouse, AM966 reduced lung injury, vascular leakage, inflammation and fibrosis at multiple time points following intratracheal bleomycin instillation. AM966 also decreased lactate dehydrogenase activity and tissue inhibitor of metalloproteinase-1, transforming growth factor beta1, hyaluronan and matrix metalloproteinase-7, in bronchoalveolar lavage fluid.
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同义词AM-966; AM 966; AM966
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通路Others
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靶点Other Targets
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受体LPA1
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number1228690-19-4
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分子量490.94
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分子式C27H23ClN2O5
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纯度98%
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溶解度DMSO : ≥ 105 mg/mL. 213.88 mM
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SMILESO=C(O)CC(C=C1)=CC=C1C(C=C2)=CC=C2C3=C(NC(O[C@H](C)C4=C(Cl)C=CC=C4)=O)C(C)=NO3
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化学全称(4'-(4-((R)-1-(2-Chlorophenyl)ethoxycarbonylamino)-3-methylisoxazol-5-yl)biphenyl-4-yl)acetic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Swaney, JS, et al. A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br J Pharmacol. 2010 Aug;160(7):1699-713.
产品手册
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