ALC-0315 ( —— )

产品货号. M37618 CAS No. 2036272-55-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ALC-0315
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ALC-0315 是一种可电离的氨基脂质，负责 mRNA 压缩，帮助 mRNA 的细胞传递和胞质释放。ALC-0315 可作为脂质纳米粒 (LNP) 运载工具的组分之一。脂质纳米粒已经用于 mRNA (COVID-19) 疫苗的研究。
产品描述

ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
体外实验

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体内实验

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同义词

——
通路

Others
靶点

Other Targets
受体

Others
研究领域

——
适应症

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CAS Number

2036272-55-4
分子量

766.27
分子式

C48H95NO5
纯度

>98% (HPLC)
溶解度

In Vitro:?Ethanol 中的溶解度 : 100 mg/mL (130.50 mM; 超声助溶) DMSO 中的溶解度 : 50 mg/mL (65.25 mM; 超声助溶 )
SMILES

CCCCCCCCC(CCCCCC)C(=O)OCCCCCCN(CCCCO)CCCCCCOC(=O)C(CCCCCC)CCCCCCCC
化学全称

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1. Moghimi SM. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Mol Ther. 2021;29(3):898-900.?

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