
AER-271
CAS No. 634913-39-6
AER-271 ( AER271 )
产品货号. M15401 CAS No. 634913-39-6
AER-271 (AER271) 是水通道蛋白 4 (AQP4) 的选择性小分子抑制剂,AQP4 是 AER-270 的前药,具有增强的溶解度。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥300 | 有现货 |
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5MG | ¥478 | 有现货 |
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10MG | ¥851 | 有现货 |
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25MG | ¥1847 | 有现货 |
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50MG | ¥2803 | 有现货 |
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100MG | ¥4204 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称AER-271
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述AER-271 (AER271) 是水通道蛋白 4 (AQP4) 的选择性小分子抑制剂,AQP4 是 AER-270 的前药,具有增强的溶解度。
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产品描述AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility; shows improved neurological outcome and reduced swelling in two models of CNS injury complicated by cerebral edema.Other Indication Phase 1 Clinical(In Vivo):AER-271 is converted in vivo to AER-270 by endogenous phosphatases. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.AER-271 reduces cerebral edema and improves neurological outcomes in rodent ischemic stroke models. Mice treated with AER-271 (5?mg/kg; i.p. injection) show improved outcomes and reduced cerebral edema in a model of ischemic stroke.
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体外实验——
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体内实验Animal Model:Male mice (C57BL/6J, 8-12?week-old, 25-30?g)Dosage:5?mg/kg Administration:Treated by i.p. injection Result:Had better outcomes with an average neurological score of 0.89±0.31 compared with control mice receiving vehicle had an average neurological score of 2.50±0.62.
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同义词AER271
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number634913-39-6
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分子量463.653
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分子式C15H9ClF6NO5P
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (269.60 mM)
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SMILESO=P(O)(OC1=CC=C(Cl)C=C1C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)O
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化学全称2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Farr GW, et al. Neuroscience. 2019 Feb 6. pii: S0306-4522(19)30054-5.
2. Wallisch JS, et al. Pediatr Res. 2018 Oct 26. doi: 10.1038/s41390-018-0215-5.
产品手册




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