ADX88178

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.

ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.

ADX-88178; ADX 88178; ADX88178

Others

Other Targets

human mGluR4

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1235318-89-4

272.33

C12H12N6S

98%

DMSO : ≥ 50 mg/mL 183.60 mM

Cc1nc(Nc2nc(c3c[nH]nc3)c(C)s2)ncc1

5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine

(-20℃)

With Ice Pack

≥ 2 years