ACTB-1003
CAS No. 939805-30-8
ACTB-1003 ( ACTB1003; ACTB 1003; ACTB-1003 )
产品货号. M19271 CAS No. 939805-30-8
ACTB-1003 is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1110 | 有现货 |
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5MG | ¥1604 | 有现货 |
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10MG | ¥2811 | 有现货 |
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25MG | ¥4771 | 有现货 |
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50MG | ¥6820 | 有现货 |
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100MG | ¥9396 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称ACTB-1003
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述ACTB-1003 is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).
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产品描述ACTB-1003 is an oral kinase inhibitor targeting cancer mutations (FGFR inhibition), angiogenesis (inhibition of VEGFR2 and Tie-2) and induces apoptosis (targeting RSK and p70S6K, downstream of PI3 kinase). The multi-activity of ACTB- 1003 translates to in vivo efficacy with dose-dependent tumor growth inhibition in a variety of histological cancers including lung, breast and colorectal. ACTB-1003 is an oral kinase inhibitor with multiple modes of action, targeting cancer mutations via FGFR inhibition FGFR1 (IC50=6 nM), angiogenesis through inhibition of VEGFR2 (2 nM), Tie-2 (4 nM), and induces apoptosis likely by targeting RSK (5 nM) and p70S6K (32 nM). ACTB-1003 is highly active with dose-dependent tumor growth inhibition in cell lines with FGFR genetic alterations - OPM2 human multiple myeloma and the murine leukemia Ba/F3-TEL-FGFR1.
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同义词ACTB1003; ACTB 1003; ACTB-1003
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通路Others
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靶点Other Targets
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受体FGFR1,VEGFR2,Tie-2
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研究领域Cancer
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适应症——
化学信息
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CAS Number939805-30-8
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分子量591.54
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分子式C27H26F5N7O3
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纯度98%
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溶解度DMSO : ≥ 35 mg/mL; 59.17 mM
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SMILESCOCC1=C(N2C(=C1C3=CC(=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)F)C(=NC=N2)N)CN5CCOCC5
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化学全称1-(4-(4-amino-6-(methoxymethyl)-7-(morpholinomethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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