
ACH-000143
CAS No. 2225836-30-4
ACH-000143 ( —— )
产品货号. M24008 CAS No. 2225836-30-4
ACH-000143 已被鉴定为褪黑激素受体 MT1 和 MT2 的新型激动剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2001 | 有现货 |
![]() ![]() |
10MG | ¥3183 | 有现货 |
![]() ![]() |
25MG | ¥5330 | 有现货 |
![]() ![]() |
50MG | ¥7590 | 有现货 |
![]() ![]() |
100MG | ¥10287 | 有现货 |
![]() ![]() |
500MG | ¥20655 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称ACH-000143
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述ACH-000143 已被鉴定为褪黑激素受体 MT1 和 MT2 的新型激动剂。
-
产品描述ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
-
体外实验——
-
体内实验ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats.ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate.ACH-000143 significantly reduces plasma glucose at 10 mg/kg (?16.4%, p < 0.05) and 30 mg/kg (?16.9%, p < 0.01). Animal Model:High-fat diet rats.Dosage:10 and 30 mg/kg.Administration:Orally, once daily for two months.Result:Significantly reduced the weekly BW gain on weeks.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体MT1 receptor|MT2 receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number2225836-30-4
-
分子量297.74
-
分子式C13H16ClN3O3
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 50 mg/mL (167.93 mM)
-
SMILESCC(NCCN1C2=CC(OC)=C(Cl)C=C2N=C1OC)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.
产品手册




关联产品
-
VUF 5574
人腺苷 A3 受体拮抗剂。
-
MARK4 inhibitor 1
MARK4抑制剂1抑制癌细胞增殖、转移并诱导细胞凋亡。 MARK4抑制剂1是一种有效的微管亲和力调节激酶4 (MARK4)抑制剂,IC50为1.54 μM。
-
Phytic acid dodecaso...
植酸十二钠盐水合物是种子和谷物的磷储存化合物。