AC1NS4RE ( SU5614; SU 5614; SU5614 )

产品货号. M17129 CAS No. 1055412-47-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AC1NS4RE
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3.
产品描述

SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21.
同义词

SU5614; SU 5614; SU5614
通路

Others
靶点

Other Targets
受体

Others
研究领域

Cancer
适应症

——

CAS Number

1055412-47-9
分子量

272.73
分子式

C15H13ClN2O
纯度

98%
溶解度

——
SMILES

Cc1cc(c([nH]1)/C=C\1/c2c(ccc(c2)Cl)NC1=O)C
化学全称

(3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one

计算器

产品手册

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