AAI-101

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases.

AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases; is currently in clinical development as a combination with cefepime, reduces the MIC50 of cefepime against a collection of 223 cefepime-nonsusceptible isolates of the family Enterobacteriaceae from >64 mg/L to 0.125 mg/L.Bacterial Infection Phase 1 Clinical

AAI 101;AAI101

GPCR/G Protein

Antibacterial

Antibacterial

Infection

Bacterial Infection

1001404-83-6

314.32

C11H14N4O5S

>98% (HPLC)

DMSO : ≥ 113.3 mg/mL 360.46 mM

C[N+]1=NN(C[C@@](S([C@]2([H])C3)(=O)=O)(C)[C@H](C([O-])=O)N2C3=O)C=C1

(2S,3S,5R)-3-methyl-3-((1-methyl-1H-1,2,3-triazol-3-ium-3-yl)methyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

(-20℃)

With Ice Pack

≥ 2 years