A-205804

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A-205804 是一种特异性有效的 E-选择素 (IC50=20 nM) 和 ICAM-1 (IC50=25 nM) 表达抑制剂。

A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.

A-205804 exhibits Cellular Toxicities for HUVEC with an IC50 of152 μM.A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system.

A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat.A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice. Animal Model:C57BL/6 miceDosage:10 mg/kg Administration:Oral administration, 3 times per week, for 2 weeks Result:Efficiently decreased the expression of E-selectin on the endothelial vascular niche cells Animal Model:Rat Dosage:5 mg/kg (Pharmacokinetic Analysis)Administration:Oral administration Result:t1/2 = 1 hour.

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Autophagy

Sigma receptor

E-selectin| ICAM-1

Cancer

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251992-66-2

300.41

C15H12N2OS2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (332.89 mM)

Cc1ccc(cc1)Sc1c2cc(sc2cnc1)C(=O)N

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(-20℃)

With Ice Pack

≥ 2 years