A-1048400 ( A1048400 )

产品货号. M10826 CAS No. 1219624-62-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

A-1048400
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种新型有效、选择性、口服活性的 N 型和 T 型钙通道阻滞剂，IC50 分别为 1.4 和 1.2 uM。
产品描述

A novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively; shows no significant activity against L-type Ca2+ channels (IC50=28 uM); reverses tactile allodynia in model of capsaicin-induced secondary hypersensitivity (EC50=300-365 ng/ml), without effect on hemodynamic function; blocks native N- and T-type Ca2+ currents in rat dorsal root ganglion neurons (IC50=3.0 and 1.6 uM), attenuates nociceptive, neuropathic and inflammatory pain in vivo.Pain Discontinued.
体外实验

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体内实验

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同义词

A1048400
通路

GPCR/G Protein
靶点

Calcium Channel
受体

Calcium Channel
研究领域

Neurological Disease
适应症

Pain

CAS Number

1219624-62-0
分子量

543.711
分子式

C36H37N3O2
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C1N(CC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)CCCC1(C5=CC=CC=C5)C6=CC=CC=C6
化学全称

1-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one

1. Scott VE, et al. Biochem Pharmacol. 2012 Feb 1;83(3):406-18.

计算器

产品手册

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