8-Epixanthatin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

8-Epixanthatin 是一种潜在的秋水仙碱结合位点抑制剂，从Xanthium chinese Mill 中分离得到。8-Epixanthatin 可以抑制 STAT3 的激活，诱导细胞凋亡( apoptosis)，具有抗肿瘤活性。

8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. 8-Epixanthatin can inhibit the activation of STAT3, induce apoptosis, and has anti-tumor activity.

8-Epixanthatin (i.p., 50 mg/kg, 5 days per week for 25 days) 在 DU145 细胞的小鼠异种移植模型中，可以通过 STAT3 失活抑制肿瘤生长，小鼠肿瘤体积减少了40.1%，肿瘤重量减少了40.0%，肿瘤中 p-STAT3 水平显著降低。

8-Epixanthatin(2-20 μM, 12 h) 可以以剂量依赖性方式抑制 DU145 细胞增殖和 DU145 细胞的 p-STAT3 水平，其 IC50 值为 3.2 μM。 8-Epixanthatin可以通过诱导 DU145 癌细胞中 ROS 的产生抑制 STAT3 的激活和细胞增殖。Cell Proliferation Assay Cell Line:DU145 cell Concentration:2, 5, 10, and 20 μM Incubation Time:12 h or 48 h Result:Reduced STAT3 phosphorylation by 90% at a concentration of 20 μM but not p-JAK2-Y1007/1008.Significantly reduced the amount of BCL-2 and BCL-xL, and induces BCL-xL PARP cleavage, the percentage of cells in G0/G1 phase decreased.

8-表苍耳亭

Microbiology/Virology

Antifection

Antifection

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30890-35-8

246.3

C15H18O3

>98% (HPLC)

DMSO : 50 mg/mL (203.00 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years