7α,25-Dihydroxycholesterol ( 7α,25-OHC )

产品货号. M22488 CAS No. 64907-22-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

7α,25-Dihydroxycholesterol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM).
产品描述

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells, and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM. but it had no effect on EBI2-deficient cells.EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen.
同义词

7α,25-OHC
通路

Proteasome/Ubiquitin
靶点

Endogenous Metabolite
受体

Human Endogenous Metabolite;GPR183
研究领域

——
适应症

——

CAS Number

64907-22-8
分子量

418.65
分子式

C27H46O3
纯度

>98% (HPLC)
溶解度

DMSO:1 mg/mL?(2.39 mM;?Need ultrasonic)
SMILES

[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)(C)O
化学全称

——

1. Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.

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