7BIO

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

7-bromoindirubin-3'-oxime (7BIO) 是一种不依赖半胱天冬酶的非凋亡细胞死亡诱导剂。 7BIO 是 FLT3、DYRK1A、DYRK2、Aurora B 和 Aurora C 激酶的抑制剂。

7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.

7BIO (1 and 10 μM; 24 hours) has neuroprotective effects and can prevent, but cannot rescue Aβ1?42 oligomer-induced cell death in SH-SY5Y cells. Cell Viability AssayCell Line:SH-SY5Y cellsConcentration:1 and 10 μMIncubation Time:24 hoursResult:Inhibit Aβ oligomer-induced neuronal death. 7BIO prevented, but did not rescue Aβ1?42 oligomer-induced cell death in SH-SY5Y cells.

7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) significantly attenuates Aβ oligomer-induced impairment of recognition, spatial learning and memory in mice.7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) decreases Aβ oligomer-induced increase of TNF-α and IL-6 production in the brain and the expression of synapsin-1 and PSD-95 in the hippocampal region of mice.7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) attenuates Aβ oligomer-induced increase expression of pTau, activation of microglia and astrogliosis in the brain of mice.7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) prevents decreased expression of pSer9-GSK3β and has no significant effects on the Tau protein level. Animal Model:8 weeks mice (30 g)Dosage:2.3, 7.0, and 23.3 μg/kg Administration:bilateral ventricle injection Result:Attenuates Aβ oligomer-induced impairment of recognition, spatial learning and memory in mice.

——

Angiogenesis

FLT

glutamine synthetase

——

——

916440-85-2

356.179

C16H10BrN3O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (701.91 mM)

O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2c1cccc2Br

——

(-20℃)

With Ice Pack

≥ 2 years