
6RK73
CAS No. 1895050-66-4
6RK73 ( —— )
产品货号. M26038 CAS No. 1895050-66-4
6RK73 是一种共价不可逆的特异性 UCHL1 抑制剂 (IC50: 0.23 μM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2535 | 有现货 |
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10MG | ¥4350 | 有现货 |
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25MG | ¥7039 | 有现货 |
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50MG | ¥9639 | 有现货 |
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100MG | ¥12879 | 有现货 |
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500MG | ¥26082 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称6RK73
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述6RK73 是一种共价不可逆的特异性 UCHL1 抑制剂 (IC50: 0.23 μM)。
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产品描述6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 μM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 μM).(In Vitro):6RK73 (5 μM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells. 6RK73 (5 μM; 24-48 hours) results in migration significantly slower than the DMSO control group in MDA-MB-436 cells.(In Vivo):6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish.
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体外实验Cell Viability Assay Cell Line:MDA-MB-436 cells Concentration:5 μM Incubation Time:24, 48 hours Result:Migrated significantly slower than the DMSO control group Western Blot Analysis Cell Line:MDA-MB-436 cells Concentration: 5 μM Incubation Time:1, 2, 3 hours Result:Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Antioxidant
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研究领域——
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适应症——
化学信息
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CAS Number1895050-66-4
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分子量307.37
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分子式C13H17N5O2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (406.68 mM)
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SMILESO=C(Nc1ncc(s1)N1CCOCC1)[C@H]1CCN(C1)C#N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Safranal Attenuates Excitotoxin-Induced Oxidative OLN-93 Cells Injury
产品手册




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